Production of functional chimaeric mouse/human antibody

Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion

Georges Köhler, César Milstein · European Journal of Immunology · 1976 · 1.9K citations

Life Sciences, Immunology, Oncology +12

A better cell line for making hybridomas secreting specific antibodies

Marc J. Shulman, C. Deborah Wilde, Georges Köhler · Nature · 1978 · 1.6K citations

Life Sciences, Cell Biology, Immunology +9

Transformation of mammalian cells with genes from procaryotes and eucaryotes

Michael Wigler, Raymond W. Sweet, Gek Kee Sim et al. · Cell · 1979 · 1.5K citations

Life Sciences, Genetics, Molecular Genetics +11

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

Richard Mulligan, Paul Berg · Proceedings of the National Academy of Sciences · 1981 · 1K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments

Philip Hieter, Edward E. Max, J.G. Seidman et al. · Cell · 1980 · 399 citations

Life Sciences, Genetics, Molecular Biology +11