Concepedia

A better cell line for making hybridomas secreting specific antibodies

Marc J. Shulman, C. Deborah Wilde, Georges Köhler

Nature · 1978 · 1.6K citations · 8 references

DOI

Concepts

References

8

Continuous cultures of fused cells secreting antibody of predefined specificity

Georges Köhler, César Milstein · Nature · 1975 · 17.2K citations

, , +11

Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion

Georges Köhler, César Milstein · European Journal of Immunology · 1976 · 1.9K citations

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Antibodies to major histocompatibility antigens produced by hybrid cell lines

G. Galfré, Sebastian Howe, César Milstein et al. · Nature · 1977 · 1.7K citations

, , +14

A plaque assay for all cells secreting Ig of a given type or class

E. GRONOWICZ, António Coutinho, Fritz Melchers · European Journal of Immunology · 1976 · 1K citations

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Somatic mutation and the origin of antibody diversity. Clonal variability of the immunoglobulin produced by MOPC 21 cells in culture

Richard G.H. Cotton, David S. Secher, César Milstein · European Journal of Immunology · 1973 · 143 citations

, , +17