A Novel, Potent, and Selective 5-HT₇Antagonist: (<i>R</i>)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTA Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)Peter J. Lovell, Steven M. Bromidge, Steven Dabbs, D. Malcolm Duckworth, Ian T. Forbes, Andrew J. Jennings, Frank D. King, Derek N. Middlemiss, Shirley K. Rahman, Damian V. Saunders, Lissa L. Collin, Jim J. Hagan, Graham J. Riley, and David R. ThomasView Author Information SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex CM19 5AW, U.K. Cite this: J. Med. Chem. 2000, 43, 3, 342–345Publication Date (Web):January 21, 2000Publication History Received27 August 1999Published online21 January 2000Published inissue 1 February 2000https://pubs.acs.org/doi/10.1021/jm991151jhttps://doi.org/10.1021/jm991151jrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1949Altmetric-Citations212LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Antagonists,Receptors,Rodent models,Selectivity Get e-Alerts