Concepedia

Direct determination of the enantiomeric ratio of verapamil, its major metabolite norverapamil and gallopamil in plasma by chiral high-performance liquid chromatography

Hiltrud Fieger, Gottfried Blaschke

Journal of Chromatography B Biomedical Sciences and Applications · 1992 · 33 citations · 10 references

DOI

Concepts

References

10

Stereoselective first‐pass metabolism of highly cleared drugs: studies of the bioavailability of L‐ and D‐verapamil examined with a stable isotope technique.

B. Vogelgesang, H Echizen, Elke Schmidt et al. · British Journal of Clinical Pharmacology · 1984 · 180 citations · Full text

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Pharmacokinetics of (+)‐, (‐)‐ and (+/‐)‐verapamil after intravenous administration.

Michel Eichelbaum, Gerd Mikus, B. Vogelgesang · British Journal of Clinical Pharmacology · 1984 · 179 citations · Full text

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Enantiomeric separation of drugs and related compounds based on their interaction with α1-acid glycoprotein

Jörgen Hermansson · TrAC Trends in Analytical Chemistry · 1989 · 155 citations

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Effects of d,l-verapamil on atrioventricular conduction in relation to its stereoselective first-pass metabolism

Hirotoshi Echizen, B. Vogelgesang, Michel Eichelbaum · Clinical Pharmacology & Therapeutics · 1985 · 114 citations

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Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism) — Increased michaelis constant (km) and loss of stereoselectivity of bufuralol 1′-hydroxylation in poor metabolizers

Pierre Dayer, Rodolfo Gasser, J. Gut et al. · Biochemical and Biophysical Research Communications · 1984 · 66 citations

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