Hirotoshi Echizen

Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans

Harumi Takahashi, G. Wilkinson, Edith A. Nutescu et al. · Pharmacogenetics and Genomics · 2006 · 374 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +16

Population differences in S‐warfarin metabolism between <i>CYP2C9</i> genotype‐matched Caucasian and Japanese patients

Harumi Takahashi, G. Wilkinson, Yoseph Caraco et al. · Clinical Pharmacology & Therapeutics · 2003 · 189 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes*

Harumi Takahashi, Toshitaka Kashima, Yuko Nomizo et al. · Clinical Pharmacology & Therapeutics · 1998 · 184 citations

Medicine, Pharmacokinetics, Pharmacology +17

Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes

Harumi Takahashi, Toshitaka Kashima, Shinichi Nomoto et al. · Pharmacogenetics · 1998 · 163 citations

Medicine, Pharmacokinetics, Pharmacology +17

The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans

Hirotoshi Echizen, Thomas Brecht, Sabine Niedergesäss et al. · American Heart Journal · 1985 · 135 citations

Medicine, Cardiology, Pharmacology +14