Uveal Melanoma Expression of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL) Receptors and Susceptibility to TRAIL-Induced Apoptosis

Abstract

TRAIL is a potentially useful therapeutic modality for the management of uveal melanomas and their metastases. Moreover, pharmacological agents and biological response modifiers that independently display antineoplastic properties can enhance TRAIL-induced apoptosis in resistant uveal melanoma cells.