Inhibition of death receptor signals by cellular FLIP

Martin Irmler, Margot Thome, Michael Hahne, +10

Nature

Signal TransductionCell SignalingMedicineApoptosisReceptor (Biochemistry) +6

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Nils Holler, Rossana Zaru, Olivier Micheau, +7

Nature Immunology

Kinase RipSignal TransductionSignaling PathwayCell RegulationMedicine +9

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

Margot Thome, Pascal Schneider, Kay Hofmann, +11

Nature

MedicineApoptosisPrevent ApoptosisAntiviral ResponseCell Death +4

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

Pascal Schneider, Margot Thome, Kim Burns, +5

Immunity

Trail Receptors 1Signal TransductionSignal Fadd-dependent ApoptosisSignaling PathwayMedicine +8

The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways

Takao Kataoka, Ralph C. Budd, Nils Holler, +8

Current Biology

InflammationSignal TransductionSignaling PathwayErk Signaling PathwaysCell Regulation +8

The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex

Olivier Micheau, Margot Thome, Pascal Schneider, +5

Journal of Biological Chemistry

CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

Olivier Gaide, Benoı̂t Favier, Daniel F. Legler, +6

Nature Immunology

InflammationCytokineMolecular ImmunologyCritical LipidSignal Transduction +10

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

Margot Thome, Kay Hofmann, Kim Burns, +4

Current Biology

Signal TransductionMolecular PhysiologySignaling PathwayApoptosisCell Death +8

Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas

David Vallois, Maria Pamela Dobay, Ryan D. Morin, +23

Blood

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

Fabien Rebeaud, Stephan Hailfinger, Anita Posevitz‐Fejfár, +9

Nature Immunology

T-regulatory CellImmunologyPathologyCell DeathImmunologic Mechanism +15