Synthetic Communications · 1980 · 16 citations · 4 references
Natural SciencesChemistryDrug DiscoveryGreen ChemistryOrganic ChemistryPhenolic Compound AnalysisProtecting-group StrategyHydrolysisPhenol Protecting GroupsPhenolic CompoundsProtecting Group Chemistry
Abstract Hemithioacetals have previously found utility as protecting groups for alcohols and phenols. In particular, the protection of alcohols2,3,4 and phenols5 as methylthiomethyl (MTM) ethers, and the facile hydrolysis of these ethers back to the parent alcohol or phenol have been reported. We now wish to report the use of phenylthiomethyl (PTM) ethers as phenolic protecting groups which may be differentiated from phenolic MTM ethers.
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Protection of tertiary hydroxyl groups as methylthiomethyl ethers
Kiyoyuki Yamada, Kaneyoshi Kato, Hiroshi Nagase et al. · Tetrahedron Letters · 1976 · 50 citations