Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids

Kaneyoshi Kato, Shinji Terao, Norio Shimamoto, +1

Journal of Medicinal Chemistry

Bioorganic ChemistryLipid PeroxidationOrganic ChemistryChemistryRedox Biology +16

T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist

Shiro Takekawa, Asano Asami, Yuji Ishihara, +9

European Journal of Pharmacology

Functional SelectivityMedicineHormonal ReceptorPhysiologyMechanism Of Action +5

A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates Aβ Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease

Hiroaki Fukumoto, Hideki Takahashi, Naoki Tarui, +13

Journal of Neuroscience

Neurochemical BiomarkersSynaptic SignalingNeuroinflammationAlzheimer's DiseaseDegenerative Pathology +18

Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of .omega.-pyridylalkenoic acids

Kaneyoshi Kato, Shigenori Ohkawa, Shinji Terao, +2

Journal of Medicinal Chemistry

Bioorganic ChemistryOrganic ChemistryPharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +17

Protection of tertiary hydroxyl groups as methylthiomethyl ethers

Kiyoyuki Yamada, Kaneyoshi Kato, Hiroshi Nagase, +1

Tetrahedron Letters

Chemical SafetyOrganic ChemistryChemistryMethylthiomethyl EthersPersistent Organic Pollutant

Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation

Mitsuru Shiraishi, Kaneyoshi Kato, Shinji Terao, +3

Journal of Medicinal Chemistry

Molecular PharmacologyPharmaceutical ScienceBioorganic ChemistryNovel Eicosanoid AntagonistsBiochemistry +13

Synthesis of ubiquinones. 2. An efficient preparation of ubiquinone-10

Shinji Terao, Kaneyoshi Kato, Mitsuru Shiraishi, +1

The Journal of Organic Chemistry

Molecular SciencesEngineeringDonut IconMedicineMass Spectrometry +11

Melanin-Concentrating Hormone Receptor 1 Antagonists. Synthesis and Structure–Activity Relationships of Novel 3-(Aminomethyl)quinolines

Makoto Kamata, Toshiro Yamashita, Toshihiro Imaeda, +17

Journal of Medicinal Chemistry

Hydrozirconation / transmetalation / alkylation: direct one-pot conversion of 1-alkynes to E-1,2-disubstituted alkenes

Bruce H. Lipshutz, Kaneyoshi Kato

Tetrahedron Letters

E-1,2-disubstituted AlkenesDirect One-pot ConversionAlkene MetathesisOrganic ChemistryEnantioselective Synthesis

Synthesis of ubiquinones. Elongation of the heptaprenyl side-chain in ubiquinone-7

Shinji Terao, Kaneyoshi Kato, Mitsuru Shiraishi, +1

Journal of the Chemical Society Perkin Transactions 1

Terminal Trans-methyl GroupBiosynthesisHeptaprenyl Side-chainEngineeringBiochemistry +11