Concepedia

Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis

Tongsen Zheng, Jiabei Wang, Yuhan Zhao, Cen Zhang, Meihua Lin, Xiaowen Wang, Haiyang Yu, Lianxin Liu, Zhaohui Feng, Wenwei Hu

Nature Communications · 2013 · 110 citations · 38 references

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38

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Reiko Honda, Hirofumi Tanaka, Hideyo Yasuda · FEBS Letters · 1997 · 1.9K citations

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Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome

Kenneth P. Olive, David A. Tuveson, Zachary C. Ruhe et al. · Cell · 2004 · 1.3K citations · Full text

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The IARC TP53 database: New online mutation analysis and recommendations to users

Magali Olivier, Rosalind A. Eeles, Monica Hollstein et al. · Human Mutation · 2002 · 1.3K citations

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Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome

Gene A. Lang, Tomoo Iwakuma, Young‐Ah Suh et al. · Cell · 2004 · 1.1K citations · Full text

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

Christine M. Eischen, Jason D. Weber, Martine F. Roussel et al. · Genes & Development · 1999 · 826 citations · Full text

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