Administration of Hsp70 in vivo inhibits motor and sensory neuron degeneration

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

Alexzander Asea, Stine‐Kathrein Kraeft, Evelyn A. Kurt‐Jones et al. · Nature Medicine · 2000 · 1.6K citations

Inflammation, Cytokine, Autoimmune Disease +12

Novel Signal Transduction Pathway Utilized by Extracellular HSP70

Alexzander Asea, Michael Rehli, Edith Kabingu et al. · Journal of Biological Chemistry · 2002 · 1.5K citations · Full text

Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

Paul J. Muchowski, Gregor Schaffar, Annie Sittler et al. · Proceedings of the National Academy of Sciences · 2000 · 669 citations · Full text

Protein Assembly, Molecular Biology, Protein Phase Separation +18

Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.

William J. Welch, Joseph Suhan · The Journal of Cell Biology · 1986 · 507 citations · Full text

Amino Acid Analogue, Cytoskeleton, Cellular Physiology +24

The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones.

Ryo Morimoto, Michael Kline, David N. Bimston et al. · PubMed · 1997 · 437 citations

Protein Assembly, Molecular Regulation, Molecular Biology +20