Concepedia

Protein Phase Separation

Protein Phase Separation is a biophysical process in which proteins undergo liquid-liquid phase separation to form membrane-less organelles or condensates through multivalent, intrinsically disordered interactions that drive subcellular compartmentalization.

751

Publications

74.4K

Citations

2.9K

Authors

799

Institutions

Publications per year

2017–2026

452

Parents

Publications

751

Phase separation of integral membrane proteins in Triton X-114 solution.

C. Bordier · Journal of Biological Chemistry · 1981 · 3.3K citations · Full text

, , +16

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

Amandine Molliex, Jamshid Temirov, Jihun Lee et al. · Cell · 2015 · 2.8K citations

, , +13

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

Shana Elbaum‐Garfinkle, Younghoon Kim, Krzysztof Szczepaniak et al. · Proceedings of the National Academy of Sciences · 2015 · 1.4K citations · Full text

, , +15

Phase separation of signaling molecules promotes T cell receptor signal transduction

Xiaolei Su, Jonathon A. Ditlev, Enfu Hui et al. · Science · 2016 · 1.4K citations · Full text

, , +17

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

Erik Martin, Alex S. Holehouse, Ivan Peran et al. · Science · 2020 · 1.3K citations · Full text

, , +16

1–5 of 751

Authors

2.9K

  1. JM
    Jeetain Mittal

    Lehigh University, United States

    20 publications · 4.3K citations

    19

    h-index

  2. GB
    George B. Benedek

    Massachusetts Institute of Technology, United States

    18 publications · 2K citations

    16

    h-index

  3. NL
    Nicolas L. Fawzi

    Brown University, United States

    16 publications · 2.5K citations

    14

    h-index

  4. RV
    Rohit V. Pappu

    Washington University in St. Louis, United States

    16 publications · 5.1K citations

    14

    h-index

  5. FS
    Frank Schreiber

    University of Tübingen, Germany

    12 publications · 633 citations

    12

    h-index

1–5 of 2.9K

Institutions

799

  1. University of Toronto

    Toronto, Canada

    24 h-index

    84 publications

    19.5K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    22 h-index

    51 publications

    29.1K citations

  3. University of Cambridge

    Cambridge, United Kingdom

    19 h-index

    128 publications

    29.3K citations

  4. Hospital for Sick Children

    Toronto, Canada

    18 h-index

    52 publications

    16.6K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    69 publications

    4K citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    18 h-index

    94 publications

    10.1K citations

  7. University of Chinese Academy of Sciences

    Beijing, China

    17 h-index

    99 publications

    8.6K citations

  8. Washington University in St. Louis

    St Louis, United States

    17 h-index

    53 publications

    16.8K citations

1–8 of 799

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 43 publications · 7.5K citations

    39

    h-index

  2. Nature Communications

    32 publications · 4.3K citations

    27

    h-index

  3. Annual Review of Cell and Developmental Biology

    37 publications · 1.8K citations

    23

    h-index

  4. The Journal of Physical Chemistry B

    26 publications · 1.8K citations

    22

    h-index

  5. Journal of the American Chemical Society

    JACS · 22 publications · 1.3K citations

    20

    h-index

1–5