Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

Amandine Molliex, Jamshid Temirov, Jihun Lee, +5

Cell

Complex MatterDrives Pathological FibrillizationProtein FoldingMolecular BiologyRheology +4

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

Kyung‐Ha Lee, Peipei Zhang, Hong Joo Kim, +17

Cell

BiochemistryCell OrganelleMembrane-less OrganellesNatural SciencesOrganelle Dynamic +9

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

Ian R. Mackenzie, Alexandra M. Nicholson, Mohona Sarkar, +38

Neuron

Amyotrophic Lateral SclerosisDementiaFrontotemporal DementiaNeurochemical BiomarkersNeuroscience +6

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

Fabien Llambi, Tudor Moldoveanu, Stephen W. G. Tait, +5

Molecular Cell

MitophagySignal TransductionMitochondrial FunctionMedicineNatural Sciences +7

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

Rhonda M. Perciavalle, Daniel P. Stewart, Brian Koss, +10

Nature Cell Biology

MitophagyAnti-apoptotic Mcl-1 LocalizesMitochondrial FunctionBiochemistryNatural Sciences +8

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

Si Ming Man, Rajendra Karki, Miwa Sasai, +12

Cell

Biomolecular ToolMicrobial ProteomicsMolecular BiologyCaspase-11-nlrp3 InflammasomesInflammasome +3

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

Peipei Zhang, Baochang Fan, Peiguo Yang, +4

eLife

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

Clifford S. Guy, Kate M. Vignali, Jamshid Temirov, +13

Nature Immunology

InflammationSignal TransductionAdaptive Immune SystemPathways Drive ProliferationImmunology +10

LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation

Clifford S. Guy, Diana M. Mitrea, Po-Chien Chou, +9

Nature Immunology

Signal TransductionSignaling PathwayTcr–cd3 ComplexesCell RegulationImmune Regulation +10

Nanoparticle-Free Synthesis of Fluorescent Gold Nanoclusters at Physiological Temperature

Yuping Bao, Chang Zhong, Dung M. Vu, +3

The Journal of Physical Chemistry C

NanoparticlesEngineeringNanoclusterPh StabilityNanomaterials +9