Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

Paul J. Muchowski, Gregor Schaffar, Annie Sittler, +3

Proceedings of the National Academy of Sciences

Protein AssemblyMolecular BiologyProtein Phase SeparationProtein AggregatesProtein Refolding +16

Cellular Toxicity of Polyglutamine Expansion Proteins

Gregor Schaffar, Péter Breuer, Raina Boteva, +7

Molecular Cell

Neurodegenerative DiseasesProtein FunctionIntraneural InclusionsBiochemistryNatural Sciences +10

Chaperonin TRiC Promotes the Assembly of polyQ Expansion Proteins into Nontoxic Oligomers

Christian Behrends, C.A. Langer, Raina Boteva, +8

Molecular Cell

Studying interactions of four proteins in the yeast two-hybrid system: Structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

Arnim Pause, Brett S. Peterson, Gregor Schaffar, +2

Proceedings of the National Academy of Sciences

Single particle detection and characterization of synuclein co-aggregation

Armin Giese, Benedikt Bader, Jan Bieschke, +5

Biochemical and Biophysical Research Communications

BioanalysisMolecular BiologySingle MoleculeSingle Particle DetectionMedicine +2

A Comparison of Proposed Biosimilar LA-EP2006 and Reference Pegfilgrastim for the Prevention of Neutropenia in Patients With Early-Stage Breast Cancer Receiving Myelosuppressive Adjuvant or Neoadjuvant Chemotherapy: Pegfilgrastim Randomized Oncology (Supportive Care) Trial to Evaluate Comparative Treatment (PROTECT-2), a Phase III, Randomized, Double-Blind Trial

Kimberly Blackwell, Roman Donskih, C. Michael Jones, +7

The Oncologist

LIM‐only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin

Gregor Schaffar, Junko Taniguchi, Tanja Brodbeck, +4

Journal of Neurochemistry

Rgm ADevelopmental BiologySignal TransductionSignaling PathwayProtein Function +10

Recommendations for the Development and Validation of Immunogenicity Assays in Support of Biosimilar Programs

Francesca Civoli, Aparna Kasinath, Xiaoyan Cai, +13

The AAPS Journal

VaccinationImmunohematologyAutoimmune DiseaseImmunodeficienciesVaccine Surveillance +9

Proposed biosimilar pegfilgrastim shows similarity in pharmacokinetics and pharmacodynamics to reference pegfilgrastim in healthy subjects

Roumen Nakov, Sreekanth Gattu, Jessie Wang, +3

British Journal of Clinical Pharmacology

Evaluation of the safety and immunogenicity of subcutaneous HX575 epoetin alfa in the treatment of anemia associated with chronic kidney disease in predialysis and dialysis patients

Nicole Casadevall, Vladimir Dobronravov, Kai‐Uwe Eckardt, +7

Clinical Nephrology