Concepedia

Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats

Yoshikazu Uto, Tsuneaki Ogata, Yohei Kiyotsuka, Yuko Ueno, Yuriko Miyazawa, Hitoshi Kurata, Tsuneo Deguchi, Nobuaki Watanabe, Masahiro Konishi, Ryo Okuyama,

Bioorganic & Medicinal Chemistry Letters · 2009 · 28 citations · 24 references

DOIFull text

Open access

Concepts

References

24

The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1

Makoto Miyazaki, Young‐Cheul Kim, Mark P. Gray-Keller et al. · Journal of Biological Chemistry · 2000 · 452 citations · Full text

, , +17

Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

Alan Attie, Ronald M. Krauss, Mark P. Gray-Keller et al. · Journal of Lipid Research · 2002 · 348 citations · Full text

, , +16

Phenotype of <i>fatty</i> Due to Gln269Pro Mutation in the Leptin Receptor (<i>Lepr</i>)

Streamson C. Chua, David W. White, X. Sharon Wu-Peng et al. · Diabetes · 1996 · 287 citations · Full text

, , +16

Targeted Disruption of Stearoyl-CoA Desaturase1 Gene in Mice Causes Atrophy of Sebaceous and Meibomian Glands and Depletion of Wax Esters in the Eyelid

Makoto Miyazaki, Weng Chi Man, James M. Ntambi · Journal of Nutrition · 2001 · 265 citations

, , +15

Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites

Lin Zhang, Lan Ge, Satish Parimoo et al. · Biochemical Journal · 1999 · 238 citations · Full text

, , +17