Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type I diabetes: Evidence for endothelin release by pancreatic islet β-cells

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature · 1988 · 10.8K citations · Full text

Life Sciences, Cell Biology, Physiology +9

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

Dong Xu, Noriaki Emoto, Adel Giaid et al. · Cell · 1994 · 930 citations

Life Sciences, Biochemistry, Molecular Biology +10

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

Maki Nakayama, Norio Abiru, Hiroaki Moriyama et al. · Nature · 2005 · 745 citations · Full text

Life Sciences, Endocrinology, Immunology +9

The NOD mouse model of type 1 diabetes: As good as it gets?

Mark A. Atkinson, Edward H. Leiter · Nature Medicine · 1999 · 593 citations

Medicine, Endocrinology, Immunology +9

Elevated plasma endothelin in patients with diabetes mellitus

Kazuhiro Takahashi, M.A. Ghatei, H.‐C. Lam et al. · Diabetologia · 1990 · 493 citations · Full text

Medicine, Endocrinology, Internal Medicine +4