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Microdose pharmacogenetic study of 14C-tolbutamide in healthy subjects with accelerator mass spectrometry to examine the effects of CYP2C9∗3 on its pharmacokinetics and metabolism

Pharmacokinetic ModelingHealthy SubjectsAccelerator Mass SpectrometryMedicinePhysiologically-based Pharmacokinetic ModelingMass SpectrometryPharmacogenomicsPharmacotherapyMicrodose Pharmacogenetic StudyMetabolismPharmacologyRadiation OncologyPharmacokineticsPharmacodynamic Modeling