Zenzaburo Tozuka

Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone.

Kenji Iwasaki, Toshifumi Shiraga, Kazuko Nagase et al. · Drug Metabolism and Disposition · 1993 · 106 citations

Layered Compounds. XV. Synthesis and Properties of Multilayered Cyclophanes

Tetsuo Otsubo, Shigeyoshi Mizogami, Ikuko Otsubo et al. · Bulletin of the Chemical Society of Japan · 1973 · 89 citations · Full text

Methylene Bridges, Charge-transfer Complexes, Chemical Engineering +9

Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes

Toshifumi Shiraga, Hiroki Kaneko, Kenji Iwasaki et al. · Xenobiotica · 1999 · 43 citations

Metabolomic Profiling, Pharmacotherapy, Cytochrome P450 Enzymes +21

Identification of Cytochrome P450 3A4 Modification Site with Reactive Metabolite Using Linear Ion Trap-Fourier Transform Mass Spectrometry

Hideo Yukinaga, Tomonori Takami, Shohei Shioyama et al. · Chemical Research in Toxicology · 2007 · 41 citations

Metabolomic Profiling, Chemical Biology, Toxicological Mechanism +19

Identification of Cytochrome P450 Enzymes Involved in the Metabolism of FK228, a Potent Histone Deacetylase Inhibitor, in Human Liver Microsomes

Toshifumi Shiraga, Zenzaburo Tozuka, Rika Ishimura et al. · Biological and Pharmaceutical Bulletin · 2005 · 40 citations · Full text

Chromatin, Fk228 Disappearance, Systems Biology +15