Alpha-synuclein immunoreactivity of huntingtin polyglutamine aggregates in striatum and cortex of Huntington's disease patients and transgenic mouse models

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Mihael H. Polymeropoulos, Christian Lavedan, Elisabeth Leroy et al. · Science · 1997 · 8.2K citations

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene

J. Jang‐Ho, Christoph M. Kosinski, Julie A. Kerner et al. · Proceedings of the National Academy of Sciences · 1998 · 502 citations · Full text

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

Vanessa C. Wheeler · Human Molecular Genetics · 2000 · 462 citations · Full text

Knockout Mouse, Glutamine Tract, Molecular Neuroscience +15

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA

P. Hemachandra Reddy, Maya Williams, Vinod Charles et al. · Nature Genetics · 1998 · 397 citations

Knockout Mouse, Behavioural Abnormalities, Molecular Neuroscience +11

Wild-Type and Mutant Huntingtins Function in Vesicle Trafficking in the Secretory and Endocytic Pathways

James Velier, Manho Kim, Cordula Schwarz et al. · Experimental Neurology · 1998 · 320 citations

Vesicle Trafficking, Protein Secretion, Signal Transduction +14