Concepedia

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

Marjorie J. Lindhurst, Victoria E R Parker, Felicity Payne, Julie C. Sapp, Simon A. Rudge, Julie Harris, Alison M. Witkowski, Matthijs Groeneveld, Allan Daly, Susan Huson,

Nature Genetics · 2012 · 325 citations · 25 references

DOI

Concepts

References

25

A map of human genome variation from population-scale sequencing

Nature · 2010 · 8.1K citations · Full text

, , +17

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science · 2004 · 3.4K citations

, , +11

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

Jeffrey A. Engelman, Liang Chen, Xiaohong Tan et al. · Nature Medicine · 2008 · 1.3K citations · Full text

, , +17

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

John D. Carpten, Andrew L. Faber, Candice L. Horn et al. · Nature · 2007 · 1.3K citations

, , +12

Growth retardation and increased apoptosis in mice with homozygous disruption of the <i>akt1</i> gene

William S. Chen, Pei-Zhang Xu, Kathrin Gottlob et al. · Genes & Development · 2001 · 922 citations · Full text

, , +17