Involvement of histamine H1 and H2 receptors in the regulation of STAT-1 phosphorylation: Inverse agonism exhibited by the receptor antagonists

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Ke Shuai, Curt M. Horvath, Linda H. Huang et al. · Cell · 1994 · 814 citations

Life Sciences, Immunology, Molecular Biology +15

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

Tommaso Costa, A. Herz · Proceedings of the National Academy of Sciences · 1989 · 530 citations · Full text

Medicine, Molecular Biology, Pharmacology +15

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

Takaaki Yoshimasa, David R. Sibley, Michel Bouvier et al. · Nature · 1987 · 521 citations

Life Sciences, Biochemistry, Molecular Biology +12

Modulation of TTX-R<i>I</i>_Naby PKC and PKA and Their Role in PGE₂-Induced Sensitization of Rat Sensory Neurons<i>In Vitro</i>

Michael S. Gold, Jon D. Levine, Ana M. Correa · Journal of Neuroscience · 1998 · 417 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

Graeme Milligan, Richard A. Bond, Melanie Lee · Trends in Pharmacological Sciences · 1995 · 294 citations

Medicine, Medicinal Chemistry, Pharmacology +13