Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure

Intensive Insulin Therapy in Critically Ill Patients

Greet Van den Berghe, Pieter Wouters, Frank Weekers et al. · New England Journal of Medicine · 2001 · 10K citations · Full text

Medicine, Internal Medicine, Critical Care Medicine +10

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

Derek C. Angus, Walter T. Linde‐Zwirble, Jeffrey Lidicker et al. · Critical Care Medicine · 2001 · 8.6K citations

Veterinary Medicine, Infectious Diseases, Internal Medicine +16

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Gordon R. Bernard, Jean‐Louis Vincent, Pierre‐François Laterre et al. · New England Journal of Medicine · 2001 · 6.1K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +13

Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury

Won Kon Han, Véronique Bailly, Rekha Abichandani et al. · Kidney International · 2002 · 1.9K citations · Full text

Medicine, Nephrology, Pathology +13

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

Kenyatta Cosby, Kristine Partovi, Jack H. Crawford et al. · Nature Medicine · 2003 · 1.8K citations

Life Sciences, Cardiology, Physiology +13