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EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation

Folding-defective PolypeptidesProtein FunctionBiochemistryProtein AssemblyProtein FoldingNatural SciencesEr-associated DegradationMolecular BiologyProtein MisfoldingBiomolecular InteractionProtein DegradationCovalent Aggregation