Concepedia

Misfolding Pathways

Misfolding Pathways is a theoretical construct in protein folding dynamics that specifies the ensemble of non-native, kinetically trapped conformational trajectories leading a polypeptide chain away from its functional three-dimensional structure toward aggregation-prone or dysfunctional states.

378

Publications

20.9K

Citations

1.5K

Authors

502

Institutions

Publications per year

2017–2026

73

Parents

Publications

378

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

D. Allan Drummond, Claus O. Wilke · Cell · 2008 · 1.1K citations · Full text

, , +16

Long-Range Interactions Within a Nonnative Protein

Judith Klein‐Seetharaman, Maki Oikawa, Shaun B. Grimshaw et al. · Science · 2002 · 626 citations

, , +17

Glycerol Reverses the Misfolding Phenotype of the Most Common Cystic Fibrosis Mutation

Sachiko Sato, Cristina L. Ward, Mauri E. Krouse et al. · Journal of Biological Chemistry · 1996 · 516 citations · Full text

, , +17

Specific aggregation of partially folded polypeptide chains: The molecular basis of inclusion body composition

Margaret A. Speed, Daniel I. C. Wang, Jonathan King · Nature Biotechnology · 1996 · 311 citations

, , +17

Misfolding of HLA-B27 as a Result of Its B Pocket Suggests a Novel Mechanism for Its Role in Susceptibility to Spondyloarthropathies

John P. Mear, Kathy L. Schreiber, Christian Münz et al. · The Journal of Immunology · 1999 · 282 citations · Full text

, , +15

1–5 of 378

Authors

1.5K

  1. SB
    Stephen Bottomley

    Monash University, Australia

    9 publications · 350 citations

    9

    h-index

  2. CM
    Christopher M. Dobson

    University of Cambridge, United Kingdom

    8 publications · 1.2K citations

    8

    h-index

  3. TE
    Thomas E. Creighton

    MRC Laboratory of Molecular Biology, United Kingdom

    6 publications · 499 citations

    6

    h-index

  4. CH
    Cameron Haase‐Pettingell

    Massachusetts Institute of Technology, United States

    5 publications · 556 citations

    5

    h-index

  5. DE
    Daniel E. Otzen

    Aarhus University, Denmark

    5 publications · 248 citations

    5

    h-index

1–5 of 1.5K

Institutions

502

  1. University of Cambridge

    Cambridge, United Kingdom

    13 h-index

    51 publications

    4.3K citations

  2. University of Oxford

    Oxford, United Kingdom

    12 h-index

    46 publications

    3.9K citations

  3. Monash University

    Melbourne, Australia

    10 h-index

    29 publications

    883 citations

  4. Massachusetts Institute of Technology

    Cambridge, United States

    9 h-index

    22 publications

    5.3K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    32 publications

    668 citations

  6. Scripps Research Institute

    San Diego, United States

    9 h-index

    18 publications

    1.5K citations

  7. University of Toronto

    Toronto, Canada

    8 h-index

    22 publications

    1.5K citations

  8. National University of Singapore

    Singapore, Singapore

    7 h-index

    26 publications

    775 citations

1–8 of 502

Venues

  1. Journal of Molecular Biology

    JMB · 37 publications · 2.6K citations

    29

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 26 publications · 2.2K citations

    24

    h-index

  3. Biochemistry

    29 publications · 1.3K citations

    24

    h-index

  4. Journal of Biological Chemistry

    JBC · 26 publications · 2K citations

    22

    h-index

  5. The Journal of Physical Chemistry B

    20 publications · 606 citations

    15

    h-index

1–5