Concepedia

Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys

Weirong Wang, Xiaofeng Wang, Rajitha Doddareddy, Damien Fink, Thomas McIntosh, Hugh M. Davis, Honghui Zhou

The AAPS Journal · 2013 · 47 citations · 22 references

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References

22

Ways to Fit a PK Model with Some Data Below the Quantification Limit

Stuart L. Beal · Journal of Pharmacokinetics and Pharmacodynamics · 2001 · 1.1K citations

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Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

Wenhui Wang, EQ Wang, JP Balthasar · Clinical Pharmacology & Therapeutics · 2008 · 954 citations

, , +17

General Pharmacokinetic Model for Drugs Exhibiting Target-Mediated Drug Disposition

Donald E. Mager, William J. Jusko · Journal of Pharmacokinetics and Pharmacodynamics · 2001 · 587 citations

, , +14

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

Helen J. Lachmann, Philip J. Lowe, Sandra Daniela Felix et al. · The Journal of Experimental Medicine · 2009 · 302 citations

, , +17

Siltuximab, a Novel Anti–Interleukin-6 Monoclonal Antibody, for Castleman's Disease

Frits van Rhee, Luis Fayad, Peter M. Voorhees et al. · Journal of Clinical Oncology · 2010 · 242 citations

, , +13