Development of Different Analysis Platforms with LC−MS for Pharmacokinetic Studies of Protein Drugs

Qiaozhen Lu, Xiaoyang Zheng, Thomas McIntosh, +5

Analytical Chemistry

ImmunologyQuantitative PharmacologyAntibody DrugPhysiologically-based Pharmacokinetic ModelingProtein Drugs +18

Morning spot and 24-hour urinary 6 beta-hydroxycortisol to cortisol ratios: intraindividual variability and correlation under basal conditions and conditions of CYP 3A4 induction.

Jonathan Q. Tran, Steven J. Kovacs, Thomas McIntosh, +2

PubMed

UrologyStress HormoneFree CortisolMedicineBasal Conditions +11

A Liquid Chromatography–Mass Spectrometry Method to Measure Stable Isotopic Tracer Enrichments of Glycerol and Glucose in Human Serum

Thomas McIntosh, Hirsch Davis, Dwight E. Matthews

Analytical Biochemistry

Lipid AnalysisBiochemistryMedicineBioanalysisMass Spectrometry +8

Morning Spot and 24‐Hour Urinary 6β‐Hydroxycortisol to Cortisol Ratios: Intraindividual Variability and Correlation under Basal Conditions and Conditions of CYP 3A4 Induction

Jonathan Q. Tran, Steven J. Kovacs, Thomas McIntosh, +2

The Journal of Clinical Pharmacology

Cyp 3A4GlucocorticoidCortisol RatiosBasal ConditionsReproductive Endocrinology +14

Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys

Weirong Wang, Xiaofeng Wang, Rajitha Doddareddy, +4

The AAPS Journal

Pharmacokinetic ModelingCynomolgus MonkeysMedicineImmunologyAntibody Engineering +7

Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data

Gerald J. Fetterly, Urvi Aras, Patricia D. Meholick, +9

The Journal of Clinical Pharmacology

The agronomic landspreading of coal bottom ash: Using a regulated solid waste as a resource

Nancy J. Sell, Thomas McIntosh, Charles Severance, +1

Resources Conservation and Recycling

Agronomic LandspreadingLand UseNatural Resource ManagementRegulated Solid WasteCoal Bottom Ash +7

Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice

Xi Chen, Xiling Jiang, Rajitha Doddareddy, +5

Journal of Pharmacology and Experimental Therapeutics

Cnto 3723ImmunologyImmune RegulationImmunologic MechanismImmunotherapeutics +18

Normalization of Skeletal Muscle Glycogen Synthesis and Glycolysis in Rosiglitazone-Treated Zucker Fatty Rats

Beat M. Jucker, Thomas Schaeffer, Robin E. Haimbach, +8

Diabetes

P NmrMetabolic RemodelingInsulin SignalingObesityMetabolic Syndrome +16

Type-specific protection of neonatal rats from lethal group B streptococcal infection by immune sera obtained from human volunteers vaccinated with type III-specific polysaccharide

Bernard J. De Cueninck, Toby K. Eisenstein, Thomas McIntosh, +2

Infection and Immunity

Type Iii InfectionImmunologyImmunodominanceImmunotherapyVaccine Target +14