Concepedia

Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability

Yu Seok Youn, Su Young Chae, Seulki Lee, Jae Eun Jeon, Hyong Goo Shin, Kang Choon Lee

Biochemical Pharmacology · 2006 · 65 citations · 29 references

DOI

Concepts

References

29

A role for glucagon-like peptide-1 in the central regulation of feeding

Mandy D. Turton, Donal O’Shea, I. Gunn et al. · Nature · 1996 · 1.9K citations

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Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.

Anne Flint, Anne Raben, Arne Astrup et al. · Journal of Clinical Investigation · 1998 · 1.4K citations · Full text

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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

Gang Xu, Doris A. Stoffers, Joel F. Habener et al. · Diabetes · 1999 · 1.2K citations

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Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).

Andrew A. Young, Bronislava Gedulin, Sunil Bhavsar et al. · Diabetes · 1999 · 443 citations

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Site-specific PEGylation of proteins containing unnatural amino acids

Alexander Deiters, T. Ashton Cropp, Daniel Summerer et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 264 citations · Full text

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