Concepedia

Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy

Zhuming Zhang, Qingjie Ding, Jinjun Liu, Jing Zhang, Nan Jiang, Xin‐Jie Chu, David Bartkovitz, Kin‐Chun Luk, Cheryl A. Janson, Christian Tovar,

Bioorganic & Medicinal Chemistry · 2014 · 57 citations · 27 references

DOI

Concepts

References

27

General definition of ring puckering coordinates

Dieter Cremer, J. A. Pople · Journal of the American Chemical Society · 1975 · 7.2K citations

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Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

, , +15

The p53-mdm-2 autoregulatory feedback loop.

J. Henri Bayle, David C. Olson, Arnold J. Levine · Genes & Development · 1993 · 1.8K citations · Full text

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Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska et al. · Journal of Medicinal Chemistry · 2006 · 692 citations · Full text

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