Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

A practical computer-based approach to the analysis of radioligand binding experiments

Grant A. McPherson · Computer Programs in Biomedicine · 1983 · 832 citations

Pharmacy, Biochemistry, Chemistry +10

Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents

Richard A. Glennon, Milt Titeler, J.D. McKenney · Life Sciences · 1984 · 636 citations

Medicine, Pharmacology, Neuropharmacology +3

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

Michael De Vivo, Saul Maayani · Journal of Pharmacology and Experimental Therapeutics · 1986 · 424 citations

Medicine, Neurobiology, Pharmacology +15

Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe

George K. Aghajanian, Warren E. Foote, Michael Sheard · Science · 1968 · 406 citations

Medicine, Neuroscience, Pharmacology +16