Science · 1968 · 406 citations · 12 references
MedicineNeurosciencePharmacologyDrug MetabolismNeurochemistryNeuropharmacologyAutonomic Nervous System PharmacologyMonoamine NeurochemistryNeurochemical PharmacologySerotonergic PharmacologySerotonergic SignalingPharmacology Of Serotonergic AgentsSerotonergic AgonistsSerotonergic MechanismsSerotonergic Neuronal PathwaysSerotonin AgonistsSerotonin PharmacodynamicsSerotonin SynthesisSpontaneous Neural Activity
Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased metabolism of serotonin produced by this drug.
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