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Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis

Autoimmune DiseaseBiochemistryFree CysteineMedicineNatural SciencesBioanalysisImmunologyAntibody ScreeningAutoimmunityAutoantibodiesAntibody EngineeringFab RegionLys-c Limited ProteolysisImmunochemistryImmunoglobulin EImmunotherapyProteomics