Concepedia

Fab Region Structure

Fab Region Structure is a structural domain of an antibody that constitutes the antigen-binding fragment, distinguished by its variable and constant regions of the heavy and light chains, which together form a monovalent antigen recognition site.

171

Publications

10.8K

Citations

862

Authors

287

Institutions

Publications per year

2017–2026

20

Parents

Publications

171

The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine

Pooja Sadana, Rebecca Geyer, Joern Pezoldt et al. · Journal of Biological Chemistry · 2018 · 728 citations · Full text

, , +17

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured fab in complex with antigen 1 1Edited by I. A. Wilson

Yvonne Chen, Christian Wiesmann, Germaine Fuh et al. · Journal of Molecular Biology · 1999 · 447 citations

, , +14

Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

F.A. Saul, L. Mario Amzel, Roberto J. Poljak · Journal of Biological Chemistry · 1978 · 294 citations · Full text

, , +12

Domain Interactions in the Fab Fragment: A Comparative Evaluation of the Single-chain Fv and Fab Format Engineered with Variable Domains of Different Stability

Daniela Röthlisberger, Annemarie Honegger, Andreas Plückthun · Journal of Molecular Biology · 2005 · 285 citations

, , +16

VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 å resolution and mutational analysis of the interface

Yves A. Muller, Yvonne Chen, Hans W. Christinger et al. · Structure · 1998 · 265 citations · Full text

, , +15

1–5 of 171

Authors

862

  1. RJ
    Roberto J. Poljak

    Institut Pasteur, France

    13 publications · 1.2K citations

    11

    h-index

  2. AN
    Alfred Nisonoff

    University of Illinois Urbana-Champaign, United States

    5 publications · 237 citations

    5

    h-index

  3. GB
    G.A. Bentley

    Institut Pasteur, France

    5 publications · 481 citations

    5

    h-index

  4. ES
    E.A. Stura

    Commissariat à l'Énergie Atomique et aux Énergies Alternatives, France

    5 publications · 322 citations

    5

    h-index

  5. LM
    L. Mario Amzel

    Johns Hopkins University, United States

    4 publications · 615 citations

    4

    h-index

1–5 of 862

Institutions

287

  1. Institut Pasteur

    Paris, France

    11 h-index

    56 publications

    3.9K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    33 publications

    2.2K citations

  3. Johns Hopkins University

    Baltimore, United States

    7 h-index

    24 publications

    2.6K citations

  4. Johns Hopkins Medicine

    Baltimore, United States

    7 h-index

    24 publications

    2.6K citations

  5. Scripps Research Institute

    San Diego, United States

    6 h-index

    33 publications

    1.6K citations

  6. University of Oxford

    Oxford, United Kingdom

    5 h-index

    13 publications

    619 citations

  7. Max Delbrück Center

    Berlin, Germany

    4 h-index

    9 publications

    758 citations

  8. University of Illinois Urbana-Champaign

    Urbana, United States

    4 h-index

    6 publications

    286 citations

1–8 of 287

Venues

  1. Journal of Molecular Biology

    JMB · 34 publications · 2K citations

    23

    h-index

  2. The Journal of Immunology

    JI · 10 publications · 705 citations

    10

    h-index

  3. Molecular Immunology

    8 publications · 206 citations

    8

    h-index

  4. Structure

    6 publications · 600 citations

    6

    h-index

  5. Journal of Biological Chemistry

    JBC · 6 publications · 1.2K citations

    6

    h-index

1–5