Concepedia

P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice

Roxane Darbousset, Céline Delierneux, Soraya Mezouar, Alexandre Hego, Christelle Lecut, Isabelle Guillaumat, Markus A. Riederer, Richard J. Evans, Françoise Dignat‐George, Laurence Panicot‐Dubois,

Blood · 2014 · 82 citations · 35 references

DOIFull text

Open access

Abstract

Key Points Activation of PMNs at the site of injury is required for thrombin generation. P2X1 receptor expressed on both PMNs and platelets is crucial to initiate thrombosis.

References

35

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

Eric Jaffe, Ralph L. Nachman, Carl G. Becker et al. · Journal of Clinical Investigation · 1973 · 6.9K citations · Full text

, , +17

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

Marie-Luise von Brühl, Konstantin Stark, Alexander Steinhart et al. · The Journal of Experimental Medicine · 2012 · 1.8K citations · Full text

, , +22

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

Lenka Grahl, Marie‐Luise von Bruehl, Davit Manukyan et al. · Nature Medicine · 2010 · 1.2K citations

, , +11

A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis

Cécile V. Denis, Nassia Methia, Paul S. Frenette et al. · Proceedings of the National Academy of Sciences · 1998 · 508 citations

Mechanisms of Degranulation in Neutrophils

Paige Lacy · Allergy Asthma and Clinical Immunology · 2006 · 437 citations · Full text