Antisense oligonucleotides: a systematic high-throughput approach to target validation and gene function determination

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

Life Sciences, Microbiology, Molecular Biology +10

New Goals for the U.S. Human Genome Project: 1998-2003

Francis S. Collins, Ari Patrinos, Elke Jordan et al. · Science · 1998 · 853 citations

Life Sciences, Bioinformatics, Genetics +12

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

Brett P. Monia, Elena A. Lesnik, C. Gonzalez et al. · Journal of Biological Chemistry · 1993 · 770 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +16

Drug target validation and identification of secondary drug target effects using DNA microarrays

Matthew J. Marton, Joseph L. DeRisi, Holly A. Bennett et al. · Nature Medicine · 1998 · 647 citations

Pharmacy, Bioinformatics, Molecular Biology +14

2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

Brenda F. Baker, Sidney S. Lot, Thomas P. Condon et al. · Journal of Biological Chemistry · 1997 · 377 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15