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The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology

Neurodegenerative DiseasesNeurobiology Of DiseaseAlzheimer's DiseaseAβ42 DepositionDegenerative PathologyNeuroscienceNeurologyNeurodegenerationE280a Presenilin 1NeuropathologyMedicineSynaptic SignalingBrain PathologySocial SciencesAlzheimer Mutation ProducesProtective Mechanisms