Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Hiroshi Tanaka, Hirofumi Arakawa, Tatsuya Yamaguchi et al. · Nature · 2000 · 899 citations

Genome Instability, Dna Damage, P53-dependent Cell-cycle Checkpoint +9

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

Dennis Salonga, Kathleen D. Danenberg, Martin R. Johnson et al. · PubMed · 2000 · 833 citations

Pathology, Thymidylate Synthase, Cancer Biology +18

Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators

Tetsuhiko Shirasaka, Yuji Shimamato, Hideyuki Ohshimo et al. · Anti-Cancer Drugs · 1996 · 819 citations

Studies on Fluorinated Pyrimidines

K Hartmann, Charles Heidelberger · Journal of Biological Chemistry · 1961 · 415 citations · Full text

Halogenation, Medicinal Chemistry, Bioorganic Chemistry +7

The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.

Patrick G. Johnston, Edwin R. Fisher, Howard E. Rockette et al. · Journal of Clinical Oncology · 1994 · 409 citations