Concepedia

DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site

Dana M. van Bemmel, Adam S. Brank, Ramón Eritja, Víctor E. Márquez, Judith K. Christman

Biochemical Pharmacology · 2009 · 27 citations · 47 references

DOI

Concepts

References

47

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

En Li, Timothy H. Bestor, Rudolf Jaenisch · Cell · 1992 · 4K citations

, , +14

Cellular differentiation, cytidine analogs and DNA methylation

Peter A. Jones, Shirley M. Taylor · Cell · 1980 · 1.9K citations

, , +16

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.

Francine Creusot, George Acs, J. K. Christman · Journal of Biological Chemistry · 1982 · 575 citations · Full text

, , +12

Low-Dose 5-Aza-2′-Deoxycytidine, a DNA Hypomethylating Agent, for the Treatment of High-Risk Myelodysplastic Syndrome: A Multicenter Phase II Study in Elderly Patients

P. Wijermans, Michael Lübbert, G. Verhoef et al. · Journal of Clinical Oncology · 2000 · 571 citations

, , +17

Inhibition of DNA Methylation and Reactivation of Silenced Genes by Zebularine

Jian‐Chun Cheng, Cindy Matsen, Felicidad A. Gonzales et al. · JNCI Journal of the National Cancer Institute · 2003 · 534 citations · Full text

, , +14