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Relative hydrophobicity and lipophilicity of drugs measured by aqueous two-phase partitioning, octanol-buffer partitioning and HPLC. A simple model for predicting blood–brain distribution

Pharmaceutical SciencePharmacokinetic ModelingMedicineDrug PurityBioanalysisOctanol-buffer PartitioningBlood–brain DistributionNeuroscienceCerebral Blood FlowChromatographyPharmacologyPharmacokineticsPharmacodynamic ModelingRelative HydrophobicityDrug Analysis