Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi et al. · Nature Immunology · 2002 · 2.5K citations

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The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

Florian Heil, Parviz Ahmad‐Nejad, Hiroaki Hemmi et al. · European Journal of Immunology · 2003 · 515 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

Hiromi Tanji, Umeharu Ohto, Takuma Shibata et al. · Science · 2013 · 343 citations

Life Sciences, Immunology, Molecular Biology +17

Activation of anti-hepatitis C virus responses via Toll-like receptor 7

Jong‐Dae Lee, Christina Wu, Ki Jeong Lee et al. · Proceedings of the National Academy of Sciences · 2006 · 204 citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Immunization with HIV-1 Gag Protein Conjugated to a TLR7/8 Agonist Results in the Generation of HIV-1 Gag-Specific Th1 and CD8+ T Cell Responses

Ulrike Wille-Reece, Changyou Wu, Barbara J. Flynn et al. · The Journal of Immunology · 2005 · 187 citations

Life Sciences, Immunology, Infectious Diseases +17