Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA

Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, +8

Immunity

Toll-like Receptor 7Toll-like ReceptorsDual ReceptorSingle-stranded RnaNatural Sciences +6

Toll-like receptor 8 senses degradation products of single-stranded RNA

Hiromi Tanji, Umeharu Ohto, Takuma Shibata, +5

Nature Structural & Molecular Biology

Toll-like ReceptorsSignal TransductionNatural SciencesToll-like Receptor 8Rna Biology +4

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

Umeharu Ohto, Takuma Shibata, Hiromi Tanji, +5

Nature

Toll-like ReceptorsMolecular ImmunologySignal TransductionToll-like Receptor 9Inhibitory Dna Recognition +7

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

Hiromi Tanji, Umeharu Ohto, Takuma Shibata, +2

Science

Innate Immune SystemImmunologyMolecular BiologyInnate ImmunityDimer Induced +18

Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking

Ryutaro Fukui, Shin-ichiroh Saitoh, Atsuo Kanno, +8

Immunity

InflammationToll-like ReceptorsToll-like Receptor 7Innate Immune SystemImmunology +6

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

Koichiro Takahashi, Takuma Shibata, Sachiko Akashi‐Takamura, +11

The Journal of Experimental Medicine

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands

Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, +8

Cell Reports

Crystal structure of NOD2 and its implications in human disease

Sakiko Maekawa, Umeharu Ohto, Takuma Shibata, +2

Nature Communications

Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation

Umeharu Ohto, Hanako Ishida, Takuma Shibata, +3

Immunity

Toll-like ReceptorsMolecular ImmunologySignal TransductionToll-like Receptor 9Dna Binding +8

DNase II-dependent DNA digestion is required for DNA sensing by TLR9

Mei Po Chan, Masahiro Onji, Ryutaro Fukui, +7

Nature Communications

Tlr9 LigandsMolecular RegulationDna AnalysisMolecular BiologyMolecular Genetics +14