Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

Ryutaro Fukui, Shin-ichiroh Saitoh, Fumi Matsumoto, +5

The Journal of Experimental Medicine

InflammationToll-like ReceptorsMolecular ImmunologyTlr9 LigandAutoimmune Disease +12

Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking

Ryutaro Fukui, Shin-ichiroh Saitoh, Atsuo Kanno, +8

Immunity

InflammationToll-like ReceptorsToll-like Receptor 7Innate Immune SystemImmunology +6

Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β

Tadaomi Kawashima, Akemi Kosaka, Huimin Yan, +17

Immunity

Intestinal CommensalDysbiosisMucosal ImmunologyMicrobial PathogensMedicine +10

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

Koichiro Takahashi, Takuma Shibata, Sachiko Akashi‐Takamura, +11

The Journal of Experimental Medicine

DNase II-dependent DNA digestion is required for DNA sensing by TLR9

Mei Po Chan, Masahiro Onji, Ryutaro Fukui, +7

Nature Communications

Tlr9 LigandsMolecular RegulationDna AnalysisMolecular BiologyMolecular Genetics +14

Guanosine and its modified derivatives are endogenous ligands for TLR7

Takuma Shibata, Umeharu Ohto, Shosaku� Nomura, +10

International Immunology

Combinatorial ChemistryToll-like ReceptorsSignal TransductionBiochemistryMedicine +13

TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

Shin-ichiroh Saitoh, Fumiko Abe, Atsuo Kanno, +14

Nature Communications

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing

Masahiro Onji, Atsuo Kanno, Shin-ichiroh Saitoh, +9

Nature Communications

Toll-like ReceptorsMolecular ImmunologyToll-like Receptor 9Innate Immune SystemImmunology +6

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

Atsuo Kanno, Natsuko Tanimura, Masayuki Ishizaki, +14

Nature Communications

Innate Immune SystemImmunologyInnate ImmunityImmunotherapyImmune Dysregulation +15

Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis

Makiko Hirai, Norimitsu Kadowaki, Haruyuki Fujita, +7

Blood