Identification of polymorphisms of the IκBα gene associated with an increased risk of multiple myeloma

NF-κB: Ten Years After

Patrick A. Baeuerle, David Baltimore · Cell · 1996 · 3K citations · Full text

Inflammation, Autoimmune Disease, Disease Mechanism +7

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

Vito J. Palombella, Oliver J. Rando, Alfred L. Goldberg et al. · Cell · 1994 · 2.1K citations

Transcriptional Regulation, Protein Function, Signal Transduction +14

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

Teru Hideshima, Paul G. Richardson, D Chauhan et al. · PubMed · 2001 · 1.5K citations

Proteasome Inhibitors, Human Mm Cells, Apoptosis +19

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

Keith Brown, Susan M. Gerstberger, Louise Carlson et al. · Science · 1995 · 1.4K citations

Molecular Regulation, Immunology, Transcriptional Regulation +20

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

Thomas Henkel, Thomas Machleidt, Irit Alkalay et al. · Nature · 1993 · 1.1K citations

Inflammation, Transcriptional Regulation, Signal Transduction +14