Concepedia

Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation

Tadashi Yokosuka, Wakana Kobayashi, Masako Takamatsu, Kumiko Sakata-Sogawa, Hu Zeng, Akiko Hashimoto, Hideo Yagita∥, Makio Tokunaga, Takashi Saito

Immunity · 2010 · 202 citations · 38 references

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38

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor <i>Foxp3 </i>

WanJun Chen, Wenwen Jin, Neil J. Hardegen et al. · The Journal of Experimental Medicine · 2003 · 4.6K citations · Full text

, , +17

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

Arash Grakoui, Shannon K. Bromley, Cenk Sumen et al. · Science · 1999 · 3.1K citations

, , +16

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

, , +14

Three-dimensional segregation of supramolecular activation clusters in T cells

Colin R. F. Monks, Benjamin A. Freiberg, Hannah Kupfer et al. · Nature · 1998 · 2.3K citations

, , +16

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Jason D. Fontenot, Jeffrey P. Rasmussen, Marc A. Gavin et al. · Nature Immunology · 2005 · 1.8K citations

, , +14