Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

H. T. M. Cuypers, Gerard C.M. Selten, Wim Quint et al. · Cell · 1984 · 645 citations

Life Sciences, Genetics, Molecular Biology +13

Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

Maarten van Lohuizen, Sjef Verbeek, Paul Krimpenfort et al. · Cell · 1989 · 497 citations

Medicine, Genetics, Oncology +14

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer

Harald Mikkers, John Allen, Puck Knipscheer et al. · Nature Genetics · 2002 · 377 citations

Life Sciences, Molecular Biology, Oncology +10

Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase

Kevin Qian, Lian Wang, Eugene R. Hickey et al. · Journal of Biological Chemistry · 2004 · 288 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.

Robert Amson, F Sigaux, Serge Przedborski et al. · Proceedings of the National Academy of Sciences · 1989 · 234 citations · Full text

Life Sciences, Genetics, Oncology +10