Transient folding intermediates characterized by protein engineering

Protein denaturation. C. Theoretical models for the mechanism of denaturation.

Charles Tanford · PubMed · 1970 · 1.6K citations

Life Sciences, Biochemistry, Biophysics +12

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

John F. Brandts, Herbert R. Halvorson, Maureen Brennan · Biochemistry · 1975 · 1.1K citations

Life Sciences, Biochemistry, Chemical Kinetics +8

Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR

Heinrich Röder, Gülnur A. Elöve, S. Walter Englander · Nature · 1988 · 824 citations

Life Sciences, Biochemistry, Biophysics +14

Mapping the transition state and pathway of protein folding by protein engineering

Andreas Matouschek, James T. Kellis, Luis Serrano et al. · Nature · 1989 · 707 citations

Life Sciences, Biochemistry, Molecular Biology +16

Evidence for a molten globule state as a general intermediate in protein folding

Oleg B. Ptitsyn, Roger H. Pain, Gennady V. Semisotnov et al. · FEBS Letters · 1990 · 678 citations

Life Sciences, Biochemistry, Biophysics +15