Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches - Concepedia

Concepedia

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Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches

DOI Full Paper Access

49

Citations

37

References

2014

Year

Lopamudra Das Roy, Mahnaz Sahraei, Jorge Schettini, Helen E. Gruber, Dahlia M. Besmer, Pinku Mukherjee

Abstract

In our model, neutralization of IL-17A regulates SDF-1 expression in the metastatic niches either directly or indirectly via reducing levels of IL-6 and M-CSF.

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