Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

Amnon Peled, Isabelle Petit, Órit Kollet, +11

Science

G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

Isabelle Petit, Martine Szyper‐Kravitz, Arnon Nagler, +10

Nature Immunology

MedicineStem Cell MobilizationAdult Stem CellImmunologyUp-regulating Cxcr4 +7

The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice

Amnon Peled, Órit Kollet, Tanya Ponomaryov, +9

Blood

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

David Jin, Koji Shido, Hans‐Georg Kopp, +19

Nature Medicine

InflammationCytokineCell RegulationSdf-1 Induces RevascularizationCxcr4+ Hemangiocytes +8

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

Andrea T. Hooper, Jason M. Butler, Daniel J. Nolan, +16

Cell stem cell

Regenerative MedicineDevelopmental BiologyAngiogenesisMedicineVascular Adaptation +11

The SDF-1–CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis

Isabelle Petit, David Jin, Shahin Rafii

Trends in Immunology

AngiogenesisSignaling PathwayMolecular HubVascular BiologyMedicine +3

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

Tanya Ponomaryov, Amnon Peled, Isabelle Petit, +12

Journal of Clinical Investigation

Radiation OncologyDna DamageChemokine Stromal-derived Factor-1MedicineAdult Stem Cell +13

The chemokine SDF-1 stimulates integrin-mediated arrest of CD34+ cells on vascular endothelium under shear flow

Amnon Peled, Valentin Grabovsky, Liliana Habler, +6

Journal of Clinical Investigation

CXCR4 Regulates Migration and Development of Human Acute Myelogenous Leukemia Stem Cells in Transplanted NOD/SCID Mice

Sigal Tavor, Isabelle Petit, Svetlana Porozov, +8

Cancer Research

Rapid and efficient homing of human CD34+CD38−/lowCXCR4+stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice

Órit Kollet, Asaf Spiegel, Amnon Peled, +7

Blood