The Histone Demethylase RBP2 Is Overexpressed in Gastric Cancer and Its Inhibition Triggers Senescence of Cancer Cells

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

Education, Cell Biology, Molecular Biology +15

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Wen Xue, Lars Zender, Cornelius Miething et al. · Nature · 2007 · 2.4K citations

Medicine, Cancer Biology, Oncology +16

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Thomas Kuilman, Chrysiis Michaloglou, Liesbeth C.W. Vredeveld et al. · Cell · 2008 · 2K citations · Full text

Life Sciences, Cell Biology, Immunology +14

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen, Lloyd C. Trotman, David R. Shaffer et al. · Nature · 2005 · 2K citations · Full text

Medicine, Molecular Biology, Oncology +16

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

Juan Carlos Acosta, Ana O’Loghlen, Ana Banito et al. · Cell · 2008 · 1.8K citations · Full text

Life Sciences, Cell Biology, Immunology +14