Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis - Concepedia

Concepedia

Publication | Open Access

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

DOI Full Paper Access

108

Citations

58

References

2009

Year

Manuela Basso, Samengo Giuseppina, Giovanni Nardo, Tania Massignan, Giuseppina D’Alessandro, Silvia Tartari, L Cantoni, Marianna Marino, Cristina Cheroni, Silvia De Biasi,

Abstract

Analysis of the insoluble fractions from cellular/mouse models and human tissues revealed novel aggregation-prone proteins and suggests that nitrative stress contribute to protein aggregate formation in ALS.

References

	Year	Citations
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Manuela Neumann, Deepak M. Sampathu, Linda K. Kwong, Science	2006	6.5K
Impairment of the Ubiquitin-Proteasome System by Protein Aggregation Neil Bence, Roopal M. Sampat, Ron R. Kopito Science MitophagyProteasomeMolecular BiologyCell DeathCytoskeleton	2001	2.2K
Rapid identification of proteins by peptide-mass fingerprinting Darryl Pappin, Alan J. Bleasby Current Biology BiochemistryProtein FoldingNatural SciencesPeptide LibraryMolecular Biology	1993	1.6K
Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions Benoit I. Giasson, John E. Duda, Ian Murray, Science	2000	1.5K
Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1 Lucie Bruijn, Megan K. Houseweart, Shinsuke Kato, Science	1998	1.2K
Aconitase and mitochondrial iron–sulphur protein deficiency in Friedreich ataxia Agnès Rötig, Pascale de Lonlay, Dominique Chrétien, Nature Genetics Mitochondrial FunctionBiochemistryIron MetabolismDegenerative DiseaseFriedreich Ataxia	1997	987
Degradation of oxidized proteins in mammalian cells Tilman Grune, Thomas Reinheckel, Kelvin J.A. Davies The FASEB Journal	1997	829
Oxidative damage during aging targets mitochondrial aconitase Liang‐Jun Yan, Rodney L. Levine, Rajindar S. Sohal Proceedings of the National Academy of Sciences BiologyCitric Acid CycleAgingMitochondrial FunctionBiochemistry	1997	616
Mutated Human SOD1 Causes Dysfunction of Oxidative Phosphorylation in Mitochondria of Transgenic Mice Marina Mattiazzi, Marilena D’Aurelio, Carl D. Gajewski, Journal of Biological Chemistry	2002	604
Formation of high molecular weight complexes of mutant Cu,Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis Jennifer Johnston, Muffie J. Dalton, Mark E. Gurney, Proceedings of the National Academy of Sciences Inclusion Body FormationAggregated ProteinMolecular BiologyCytoskeletonRedox Biology	2000	596

Page 1