Concepedia

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

Manuela Basso, Samengo Giuseppina, Giovanni Nardo, Tania Massignan, Giuseppina D’Alessandro, Silvia Tartari, L Cantoni, Marianna Marino, Cristina Cheroni, Silvia De Biasi,

PLoS ONE · 2009 · 108 citations · 58 references

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Abstract

Analysis of the insoluble fractions from cellular/mouse models and human tissues revealed novel aggregation-prone proteins and suggests that nitrative stress contribute to protein aggregate formation in ALS.

References

58

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

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