Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Scott Ogg, Suzanne Paradis, S Gottlieb et al. · Nature · 1997 · 2K citations

Life Sciences, Genetics, Molecular Biology +13

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery et al. · Nature · 1998 · 1.8K citations

Life Sciences, Endocrinology, Molecular Biology +12

<i>daf-16</i> : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of <i>Caenorhabditis elegans</i>

Kui Lin, Jennie B. Dorman, Aylin R. Rodan et al. · Science · 1997 · 1.5K citations

Life Sciences, Biology, Genetics +12

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

M.Dodson Michael, Rohit Kulkarni, Catherine Postic et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Medicine, Cell Biology, Endocrinology +17

Unified nomenclature for the winged helix/forkhead transcription factors

Klaus H. Kaestner, Walter Knöchel, Daniel E. Martínez · Genes & Development · 2000 · 1.2K citations · Full text

Life Sciences, Genetics, Molecular Biology +12